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A Systems Approach to Functional Medicine Utilizing Formulas Based on Allostatic Load Theory

Dr. Jeffrey Moss is a Functional Medicine Pioneer; committed to teaching the principles of a systems-based allostatic load model to motivated learners. This model makes it clear that no matter what the chief complaint; suboptimal quality of life in chronically ailing individuals is an issue of long-term cumulate environmental stressors. While one stressor may be diet, it is the excessive whole-body, metabolic response to the total stress load that is the core problem. Dozens of leading authors and experts who specialize in the study and treatment of chronic illness have named this excessive, long-term, whole-body, metabolic response to cumulative environmental stressors: “allostatic load” or allostatic overload.” By 2009, Dr. Moss found that teaching this systems based allostatic load model to receptive learners was not enough to make significant changes in quality of life in large numbers of chronically ailing individuals. In order to deliver maximum benefits, the information on this systems–based, allostatic load model also required specialized products, formulated to directly address the environmental stressors and the resultant metabolic/allostatic responses that form the basis of the most common chief complaints of these individuals. To fill this void, Dr. Moss created a truly unique brand of professional grade supplements: the Moss Nutrition Select line - formulated based on systems-based, allostatic load theory. Specifically, what makes the Moss Nutrition Select line different and special? First and foremost, they are formulated to address the most common Metabolic Imbalances that comprise allostatic load plus many of the Environmental Stressors that can lead to allostatic load. See list of Imbalances and Stressors below.


Dr Moss created an allostatic load algorithm created, found on page 3 of our 2019 catalog. It provides an overview of the major environmental stressors often encountered by the average patient, which include but are not limited to, diet. The large box highlighted in yellow provides an overview of all the metabolic imbalances than can be created when cumulative environmental stress is prolonged and allostatic responses to these stressors continue longer than what can be tolerated physiologically. If you would like a detailed explanation of this chart and how the information it contains can provide answers on how to cost effectively and efficaciously determine why even your most difficult patients are ailing and what can be done to improve health and quality of life, please feel free to contact Dr. Moss.

The most common metabolic imbalances and environmental stressors that comprise allostatic load:


  • Protein catabolism/Loss of muscle mass
  • Cortisol/Stress hormone imbalances
  • Hyperinsulinemia/Insulin resistance
  • Chronic Inflammation
  • GI Atrophy/Dysfunction/Dysbiosis
  • Loss of Detoxification Capacity
  • Suboptimal Mitochondrial numbers and function
  • Acid/Alkaline Imbalances
  • Suboptimal Fat Metabolism
  • Metabolically-Induced Micronutrient Deficiency
  • Kynurenine Pathway Imbalances
  • Increased Free Radical Activity
  • Suboptimal Thyroid Function


  • Microbial imbalance
  • Suboptimal intake of macro and micronutrients
  • Psychological stress
  • Inability to engage in optimal movement against gravity exercise

Given that this unique, cutting-edge method requires a personalized approach, rather than an assembly-line approach, our products perform best with a heath care professional’s recommendation, and are not sold in retail outlets.