The research on leucine is accumulating and showing that this amino acid has profound metabolic implications in the following areas:
- Muscle Mass Support
- Anabolic Support
- Insulin Metabolism
- Glucose Tolerance
- Energy Production
Link to Dr. Moss's newsletters on Muscle Mass & Leucine
Churchward-Venne TA et al. Leucine supplementation of a low-protein
mixed micronutrient beverage enhances myofibrillar protein synthesis in
young men: a double-blind, randomized trial. Am J Clin Nutr.
Lei J et al. Hormonal regulation of leucine catabolism in mammary epithelial cells. Amino Acids. 2013;45:531-41.
Dardevet D et al. Muscle wasting and resistance of muscle metabolism: The 'anabolic threshold concept' for adapted nutritional strategies during sarcopenia. The Scientific World Journal. 2012;2012(ID 269531).
Stark M, et al. Protein timing and its effects on muscular hypertrophy
and strength in individuals engaged in weight-training. J Int Soc Sports
Nutr. 2012 Dec 14;9(1):54.
Manders RJ, et al. Insulinotropic and Muscle Protein Synthetic Effects
of Branched-Chain Amino Acids: Potential Therapy for Type 2 Diabetes and
Sarcopenia. Nutrients. 2012 Nov 8;4(11):1664-78.
Casperson SL, et al. Leucine supplementation chronically improves muscle
protein synthesis in older adults consuming the RDA for protein. Clin
Nutr. 2012 Aug;31(4):512-9.
Breen L & Phillips SM. Skeletal muscle protein metabolism in the
elderly: Interventions to counteract the 'anabolic resistance' of
ageing. Nutrition & Metabolism. 2011;8(68).
Deutz N, et al. Muscle protein synthesis in cancer patients can be
stimulated with a specially formulated medical food. Clin Nutr. 2011
Dec; 30(6): 759-768.
Leenders M & van Loon LJC. Leucine as a pharmaconutrient to prevent
and treat sarcopenia and type 2 diabetes. Nutr Rev. 2011;69(11):660-74.
Pasiakos SM et al. Leucine-enriched essential amino acid supplementation
during moderate steady state exercise enhances postexercise muscle
protein synthesis. Am J Clin Nutr. 2011;94:809-18.
Macotela Y, et al. Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One. 2011;6(6):e21187. doi: 10.1371/journal.pone.0021187. Epub 2011 Jun 22.
Nicastro H, et al. An overview of the therapeutic effects of leucine
supplementation on skeletal muscle under atrophic conditions. Amino
Acids. 2011 Feb;40(2):287-300.
Yang J, et al. Leucine metabolism in regulation of insulin secretion from pancreatic beta cells. Nutr Rev. 2010 May;68(5):270-9.
Hayes A & Cribb PJ. Effect of whey protein isolate on strength, body
composition and muscle hypertrophy during resistance training. Curr
Opin Clin Nutr Metab Care. 2008;11:40-4.
Blomstrand E, et al. Branched-chain amino acids activate key enzymes in
protein synthesis after physical exercise. J Nutr. 2006 Jan;136(1
Short KR, et al. Age and aerobic exercise training effects on whole body
and muscle protein metabolism. Am J Physiol Endocrinol Metab. 2004