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The research on leucine is accumulating and showing that this amino acid has profound metabolic implications in the following areas:

  • Muscle Mass Support
  • Anabolic Support
  • Insulin Metabolism
  • Glucose Tolerance
  • Energy Production
  • Protein Conservation

Link to Dr. Moss's newsletters on Muscle Mass & Leucine

Leucine Research

Churchward-Venne TA et al. Leucine supplementation of a low-protein mixed micronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial. Am J Clin Nutr. 2014;99(2):276-86.

Lei J et al. Hormonal regulation of leucine catabolism in mammary epithelial cells. Amino Acids. 2013;45:531-41.

Dardevet D et al. Muscle wasting and resistance of muscle metabolism: The 'anabolic threshold concept' for adapted nutritional strategies during sarcopenia. The Scientific World Journal. 2012;2012(ID 269531).

Stark M, et al. Protein timing and its effects on muscular hypertrophy and strength in individuals engaged in weight-training. J Int Soc Sports Nutr. 2012 Dec 14;9(1):54.

Manders RJ, et al. Insulinotropic and Muscle Protein Synthetic Effects of Branched-Chain Amino Acids: Potential Therapy for Type 2 Diabetes and Sarcopenia. Nutrients. 2012 Nov 8;4(11):1664-78.

Casperson SL, et al. Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein. Clin Nutr. 2012 Aug;31(4):512-9.

Breen L & Phillips SM. Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing. Nutrition & Metabolism. 2011;8(68).

Deutz N, et al. Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food. Clin Nutr. 2011 Dec; 30(6): 759-768

Leenders M & van Loon LJC. Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes. Nutr Rev. 2011;69(11):660-74.

Pasiakos SM et al. Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis. Am J Clin Nutr. 2011;94:809-18.

Macotela Y, et al. Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One. 2011;6(6):e21187. doi: 10.1371/journal.pone.0021187. Epub 2011 Jun 22.

Nicastro H, et al. An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids. 2011 Feb;40(2):287-300.

Yang J, et al. Leucine metabolism in regulation of insulin secretion from pancreatic beta cells. Nutr Rev. 2010 May;68(5):270-9.

Hayes A & Cribb PJ. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care. 2008;11:40-4.

Blomstrand E, et al. Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr. 2006 Jan;136(1 Suppl):269S-73S.

Short KR, et al. Age and aerobic exercise training effects on whole body and muscle protein metabolism. Am J Physiol Endocrinol Metab. 2004 Jan;286(1):E92-101.