Description |
Ingredients |
Directions |
Inosine is a purine ribonucleoside widely found in plants and animals. It is comprised of the purine base hypoxanthine and the sugar D-ribose. Inosine is also found as a minor nucleoside in transfer RNA and is essential for proper translation of the genetic code.
The discovery of Inosine as a medical supplement began with the observation that multiple sclerosis (MS) patients have lower levels of uric acid than healthy individuals, or those with some other neurological disorders[2]. It has also been classically observed that patients who suffer from gout, a disorder characterized by elevated levels of uric acid, never get MS and that these two disorders are virtually mutually exclusive. Further investigations have confirmed that uric acid acts as a potent scavenger of the peroxynitrate-dependent radicals implicated in axonal degeneration and the formation of MS lesions[1,3]. This synergistic formula also contains lipoic acid, vitamin B12 (in the methylated form) which improves methylation and is critical for healthy nervous tissue, vitamin D3 and Ginkgo biloba. Vitamin D3 is an immune regulator and has been heavily researched for many autoimmune disorders. Ginkgo helps to prevent MS exacerbations. Alpha Lipoic Acid has consistently shown impressive results in a number of clinical trials for neurological disorders[5,6]. It plays many roles including raising glutathione levels shown to be low in red and white blood cells as well as cerebrospinal fluid of patients with MS.
Additional information for Doctors
Dosage Form: Vegetarian Capsule
Servings: 30
Each serving (3 capsules) contains:
Vitamin D3
(as Cholecalciferol) 3000 IU
Vitamin B12
(as Methylcobalamin) 500 mcg
Inosine 1500 mg
Alpha Lipoic Acid 300 mg
Ginkgo (Ginkgo biloba)[standardized to contain 24% Ginkgo flavone glycosides and 6% terpene lactones] 120 mg
Other Ingredients: Microcrystalline cellulose and magnesium stearate.
Recommended Usage: Take three capsules daily with meals or as directed by your healthcare practitioner.
Storage: Store in a cool, dry place. KEEP OUT OF REACH OF CHILDREN.
Warnings: This product should be used only under the supervision of a qualified health care professional. Since the primary mechanism of inosine therapy in degenerative neurological disorders, including MS, is to raise uric acid levels, and with the understanding that excessive levels of uric acid has been shown to increase the risk of gout and kidney stones, the use of inosine should be supervised by a qualified health care provider who can perform serial assessment of uric acid levels and adjust the dosage in each individual to maintain UA levels between 7 and 9 mg/dL and not greater. While studies generally report minimal, if any, side-effects at this level of UA, sensible precautions would include a recommendation to all patients on this therapy to assure adequate fluid intake (6-8 glasses of water with fresh lemon per day minimum), a low oxylate diet, limited alcohol (especially beer), and avoidance of excessive amounts of dietary and supplemental calcium.
Inosine is a purine ribonucleoside widely found in plants and animals. It is comprised of the purine base hypoxanthine and the sugar D-ribose. Inosine is also found as a minor nucleoside in transfer RNA and is essential for proper translation of the genetic code.
The discovery of Inosine as a medical supplement began with the observation that multiple sclerosis (MS) patients have lower levels of uric acid than healthy individuals, or those with some other neurological disorders[2]. It has also been classically observed that patients who suffer from gout, a disorder characterized by elevated levels of uric acid, never get MS and that these two disorders are virtually mutually exclusive. Further investigations have confirmed that uric acid acts as a potent scavenger of the peroxynitrate-dependent radicals implicated in axonal degeneration and the formation of MS lesions[1,3]. This synergistic formula also contains lipoic acid, vitamin B12 (in the methylated form) which improves methylation and is critical for healthy nervous tissue, vitamin D3 and Ginkgo biloba. Vitamin D3 is an immune regulator and has been heavily researched for many autoimmune disorders. Ginkgo helps to prevent MS exacerbations. Alpha Lipoic Acid has consistently shown impressive results in a number of clinical trials for neurological disorders[5,6]. It plays many roles including raising glutathione levels shown to be low in red and white blood cells as well as cerebrospinal fluid of patients with MS.
Dosage Form: Vegetarian Capsule
Servings: 30
Each serving (3 capsules) contains:
Vitamin D3
(as Cholecalciferol) 3000 IU
Vitamin B12
(as Methylcobalamin) 500 mcg
Inosine 1500 mg
Alpha Lipoic Acid 300 mg
Ginkgo (Ginkgo biloba)[standardized to contain 24% Ginkgo flavone glycosides and 6% terpene lactones] 120 mg
Other Ingredients: Microcrystalline cellulose and magnesium stearate.
Recommended Usage: Take three capsules daily with meals or as directed by your healthcare practitioner.
Storage: Store in a cool, dry place. KEEP OUT OF REACH OF CHILDREN.
Warnings: This product should be used only under the supervision of a qualified health care professional. Since the primary mechanism of inosine therapy in degenerative neurological disorders, including MS, is to raise uric acid levels, and with the understanding that excessive levels of uric acid has been shown to increase the risk of gout and kidney stones, the use of inosine should be supervised by a qualified health care provider who can perform serial assessment of uric acid levels and adjust the dosage in each individual to maintain UA levels between 7 and 9 mg/dL and not greater. While studies generally report minimal, if any, side-effects at this level of UA, sensible precautions would include a recommendation to all patients on this therapy to assure adequate fluid intake (6-8 glasses of water with fresh lemon per day minimum), a low oxylate diet, limited alcohol (especially beer), and avoidance of excessive amounts of dietary and supplemental calcium.
 |
DISCLAIMER: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
|
