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Dr. Jeffrey Moss, Moss Nutrition: Folic Acid Or MTHF Supplementation: Which Will Give The Best Clinical Result In Your Patients With The MTHFR Polymorphism? Certainly one of the biggest clinical concerns for nutritional practitioners today is the striking increase in methylene tetrahydrofolate reductase (MTHFR) polymorphisms in today's patient population. Further, the potential impact these polymorphisms have on which supplements to recommend and the clinical outcome of these supplements, no matter what the clinical presentation, should be considered. Should folic acid or methyltetrahydrofolate be supplemented? Is folic acid supplementation just ineffective with these patients or could it actually lead to adverse outcomes, particularly when these patients are already ingesting a diet high in processed food that has been fortified with folic acid? Could other clinically relevant polymorphisms in folate metabolism exist that may be as common as the MTHFR polymorphism? All these questions and more will be answered in this presentation.